Publications
Reporting the results of our research is critical. This concern is reflected in the high level of publications in impactful journals and in the number of posters and participations in the main world congresses, particularly in neurosciences.
Find below examples of publications, some of them authored or co-authored by BIAL scientists.
Eslicarbazepine Acetate
Trinka E, Ben-Menachem E, Kowacs PA, Elger C, Keller B, Löffler K, et al.
Published: Epilepsia [Internet]. 2018;59(2):479–91.
Costa R, Steinhoff B, Gama H, Ikedo F, Rocha JF, Soares-da-Silva P. Safety, Tolerability and Efficacy of Eslicarbazepine
Published: Drugs Aging [Internet]. 2018;
Jóźwiak S, Veggiotti P, Moreira J, Gama H, Rocha F, Soares-da-Silva P.
Published: Epilepsy & behavior : E&B [Internet]. 2018;81:1–11.
Sperling MR, Abou-Khalil B, Harvey J, Rogin JB, Biraben A, Galimberti CA, et al..
Published: Epilepsia [Internet]. 2015;56(2):244–53.
Opicapone
Ferreira JJ, Lees A, Rocha JF, Poewe W, Rascol O, Soares-da-Silva P.
Published: Eur J Neurol [Internet]. 2019;null–null.
Ferreira JJ, Lees AJ, Poewe W, Rascol O, Rocha JF, Keller B, et al.
Published: Neurology [Internet]. 2018;90(21):e1849–e1857.
Rocha JF, Falcão A, Santos A, Pinto R, Lopes N, Nunes T, et al.
Published: Eur J Clin Pharmacol [Internet]. 2014;70(9):1059–71.
Lees AJ, Ferreira J, Rascol O, Poewe W, Rocha JF, McCrory M, et al.
Published: JAMA Neurol [Internet]. 2017;74(2):197–206.
Zamicastat
Effect of zamicastat in chronic treatment on right ventricle pressure overload in the rat monocrotaline lung injury model of pulmonary hypertension
Igreja, B., Pires, N., Moser, P. and Soares-da-Silva, et al.
Published: Hypertension. 2016;68(Suppl. 1: AP238).
Effect of Chronic Treatment With Zamicastat on Right Ventricle Pressure Overload in the Rat Monocrotaline Lung Injury Model of Pulmonary Hypertension.
Igreja, B., Pires, N., Moser, P. and Soares-da-Silva, et al.
Published: The FASEB Journal. 2017;31(1 Supplement 1070.7).
Effect of zamicastat, a dopamine beta-hydroxylase inhibitor, on the monocrotaline rat model of pulmonary arterial hypertension.
Moura, E., Costa, C., Igreja B., Pires, et al.
Published: European Respiratory Society Meeting. 2020.
The Dopamine Beta-Hydroxylase Inhibitor Zamicastat Improves Survival in the Rat Monocrotaline Model of Pulmonary Arterial Hypertension.
Bonifacio M.J., Moura E., Sousa F., Igreja B., Pires N., Soares-da-Silva P.
Published: J Respir Crit Care Med. 2020;(201:A2088).
Zamicastat decreases cardiac arrhythmias in a rat model of pulmonary arterial hypertension.
Pires N., Igreja B., Magalhães L., Bonifácio M.J., Chevalier E., Soares-da-Silva P.
Published: Pulmonary Hypertension. 2020.
BIA 5-1058 is a new noncompetitive dopamine-β-hydroxylase inhibitor.
Bonifacio M.J., Sousa F., Igreja B., Loureiro A.I., Wright L.C., Soares-da-Silva P.
Published: Proceedings of the British Pharmacological Society. 2012.
In vitro Species Different Metabolism and CYP Phenotyping of Zamicastast.
Loureiro A.I., Rebouta J., Bonifácio M.J., Soares-da-Silva P.
Published: FASEB J. 2020;34(S1):1–1.
A Double-Blind, Randomised, Placebo-Controlled, Multiple Ascending Dose Study to Investigate Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Zamicastat, in Healthy Male Volunteers.
Magalhães L., Rocha F., Falcão A., Gama H., Soares-da-Silva P.
Published: American Journal of Respiratory and Critical Care Medicine. 2020;201:A3816.
A Randomized, Double-Blind, Placebo-Controlled and Open-Label, Active-Controlled, 4-Period Crossover Trial to Evaluate the Effect of Zamicastat on Cardiac Repolarization in Healthy Adult Males and Females Under Fed Conditions.
Gama H., Magalhães L., Santos A., Soares-da-Silva P.
American Journal of Respiratory and Critical Care Medicine. 2020;201:A3815.
Drug-drug interaction study between zamicastat and bosentan in healthy subjects.
Guimarães A., Santos A., Ferreira J., Magalhães L., Gama H., Soares da Silva P.
Chest. 2020;157(6):A382.
Drug-drug interaction study between zamicastat and sildenafil in healthy subjects.
Santos A., Ferreira J., Gama H., Magalhães P. Soares -da-Silva P.
European Respiratory Journal 2020 56: 1458.
Drug-drug interaction study between zamicastat and treprostinil in healthy subjects.
Magalhães L., Guimarães A.M.R., Gana H., Magalhães P., Soares-da-Silva P.
American Journal of Respiratory and Critical Care Medicine 2021;203:A3615.